Advocacy and investment on behalf of children affected by AIDS have had an impact, and the goal of eliminating mother-to-child transmission of HIV appears within reach. But for every problem solved or advance made, new challenges and constraints have arisen. This Children and AIDS: Fifth Stocktaking Report examines current data, trends and the progress that’s been made - pointing out disparities in access, coverage and outcomes - and calls for concrete actions to benefit the millions of children, women and families worldwide who bear the burden of the epidemic.